Anti-citrullinated protein antibody-positive rheumatoid arthritis associated with RS3PE syndrome-like symptoms and an elevated serum vascular endothelial growth factor level in a patient with myasthenia gravis.
نویسندگان
چکیده
A 73-year-old man with a history of myasthenia gravis (MG) was diagnosed with rheumatoid arthritis (RA) based on a history of polyarthritis and positivity for anti-citrullinated protein antibodies (ACPA). He presented with a high level of serum vascular endothelial growth factor (VEGF) and RS3PE syndrome-like pitting edema in the extremities, which improved following treatment with low-dose prednisolone. This is an interesting case of ACPA-positive RA associated with RS3PE syndrome-like pitting edema and a high VEGF level.
منابع مشابه
مقایسه ارزش تشخیصی Anti-cyclic citrullinated peptide antibody و فاکتور روماتوئید در تشخیص آرتریت روماتوئید
Abstract Background: Rheumatoid Arthritis, (RA) is a chronic inflammatory autoimmune disease with a progressive course requiring early diagnosis and treatment. The value of anti-cyclic citrullinated peptide antibodies (Anti-CCP) in the diagnosis of RA has been shown in several studies. The present study was designed to determine and compare the diagnostic value of Anti-CCP and rheumatoid fac...
متن کاملFrequency and Accuracy of Anti-Citrullinated Protein Antibodies, Prognostic Evaluation in Overall Developing to Erosive Disease in Patients with Psoriatic Seronegative Osteoarthropathy
Anti-cyclic peptide antibodies (CCP/ACPA) are directed towards synthetic citrullinated peptides and are specific markers in diagnosis of Rheumatoid arthritis. This study aimed to compare the values and acuracy of the test in anticyclic citrullinated peptides (Anti-CCP /ACPA) antibodies, rheumatoid factor (RF), C-reactive protein (CRP) and disease activity index (PASI) in early diagnosis of untr...
متن کاملRS3PE syndrome presenting as vascular endothelial growth factor associated disorder.
OBJECTIVES To characterise serum concentrations of various cytokines and detection by magnetic resonance imaging (MRI) of synovial hypervascularity in patients with remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome before and after corticosteroid treatment. METHODS Vascular endothelial growth factor(165) (VEGF(165)), tumour necrosis factor alpha (TNFalpha), and...
متن کاملThymolipoma-associated Myasthenia Gravis with High Titer of Anti-MuSKAb: A Case Report
Myasthenia Gravis (MG) is a neuromuscular junction disorder caused by pathogenic autoantibodies to some parts of the post-synaptic muscle endplates. About 85% of generalized MG patients have autoantibodies against post-synaptic acetyl-choline receptors (AChR). From the 10-15% of the remaining patients, 45-50% are positive for Muscle Specific Tyrosine Kinase-Antibody (MuSK-Ab). It is believed th...
متن کاملVascular endothelial growth factor levels and rheumatic diseases of the elderly
BACKGROUND Increasing vascular endothelial growth factor (VEGF) has been reported in remitting symmetrical seronegative synovitis with pitting edema (RS3PE) syndrome, rheumatoid arthritis (RA), polymyalgia rheumatica (PMR) and giant cell arteritis (GCA). The aim of this study was to compare VEGF levels in patients over 60 years of age who have RS3PE, RA, PMR or GCA so as to determine whether el...
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ورودعنوان ژورنال:
- Internal medicine
دوره 53 8 شماره
صفحات -
تاریخ انتشار 2014